Significant shift in microbiome composition within 4 months
~ 3x more probiotics and 50% more postbiotics1
Postbiota Science team
Study objective
This study explored how daily intake of our fermented liquid influences gut microbiome composition over time.
Study design
- 21 participants
- Daily intake of our fermented liquid (30 ml per day)
- Measurement at baseline and after 4 months
- Faecal microbiome analysis
Methodology
- DNA-based 16S rRNA gene sequencing2
- Assessment of microbiome composition and relative bacterial abundance
- Statistical comparison over time3
Example of gut profile before and after
Relative abundance per genus before intake, after 1 month and after 4 months.
Results & conclusion
Daily intake of our fermented liquid was associated with a significant shift in microbiome composition within 4 months.
In particular, a strong increase in key probiotic bacteria and postbiotic-producing bacterial activity was observed.
Figure 1 · Increase in probiotics
Lactobacillus, a key probiotic, increased to 295% after 4 months of daily intake (p<0.05). The before intake level was set at 100%, and all changes are shown relative to this.
Figure 2 · Increase in postbiotics
SCFA-producing bacteria increased to 153% after 4 months (p<0.05). The before intake level was set at 100%, and all changes are shown relative to this.
21 participants
30 ml fermented liquid per day
4 months baseline-to-follow-up period
Faecal microbiome analysis using DNA-based 16S rRNA gene sequencing, with assessment of microbiome composition and relative bacterial abundance.
Notes
1. Postbiotics refer to metabolites (e.g. SCFAs) produced by gut bacteria. The increase reflects higher levels of postbiotic-producing bacteria.
2. DNA-based 16S rRNA gene sequencing was used to profile microbial communities.
3. Statistical comparison used the Kruskal–Wallis test with Tukey–Kramer post-hoc correction for multiple comparisons.
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